Abstract: We link opposition to globalization in advanced democracies to changes in the global institutional environment. For much of the 20th century, countries such as the U.S. provided a superior institutional environment, fostering economic exchange among firms enmeshed in domestic production networks. This institutional comparative advantage eroded with the global strengthening of property rights, creating a distinct source of discontent with globalization – rooted in global institutional change and concentrated in institution-dependent production. We develop novel measures of the institution-dependence of production across industries and local economies within the U.S., and show that trade competition is more pronounced, 2016 vote shares for Donald J. Trump are higher, and attitudes toward trade are more negative in areas reliant on the production of these goods. By highlighting the role of domestic production networks, we suggest a link from global institutional dynamics to domestic politics and offer a novel explanation of globalization backlash.